Description

Buy ADB-FUBINACA Powder Buy ADB-FUBINACA Powder is a designer drug identified in synthetic cannabis blends in Japan in 2013. In 2018, it was the third-most common synthetic cannabinoid identified in drugs seized by the Drug Enforcement Agency.

The (S)-enantiomer of ADB-FUBINACA is described in a 2009 Pfizer patent and has been reported to be a potent agonist of the CB1 receptor and the CB2 receptor with EC50 values of 1.2 nM and 3.5 nM, respectively. ADB-FUBINACA features a carboxamide group at the 3-indazole position, like SDB-001 and STS-135. ADB-FUBINACA appears to be the product of rational drug design, since it differs from AB-FUBINACA only by the replacement of the isopropyl group with a tert-butyl group.

An analogue of ADB–FUBINACA, ADSB-FUB-187, containing a more functionalized carboxamide substituent was recently reported.

Technical Information Formal Name: N-[1-(aminocarbonyl)-2,2-dimethylpropyl]-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide CAS Number: 1445583-51-6 Molecular Formula: C21H23FN4O2 Formula Weight: 382.4 Purity: ?98% Formulation: A neat solid SMILES: O=C(NC(C(N)=O)C(C)(C)C)C1=NN(CC2=CC=C(F)C=C2)C3=C1C=CC=C3 InChi CodeInChI=1S/C21H23FN4O2/c1-21(2,3)18(19(23)27)24-20(28)17-15-6-4-5-7-16(15)26(25-17)12-13-8-10-14(22)11-9-13/h4-11,18H,12H2,1-3H3,(H2,23,27)(H,24,28) InChi Key: ZSSGCSINPVBLQD-UHFFFAOYSA-N DEA Schedule: I Shipping & Storage Information Storage: -20°C Shipping: Room Temperature in continental US; may vary elsewhere Stability: ? 3 years Legality In the United States, ADB-FUBINACA is a Schedule I controlled substance.

Metabolism Twenty-three ADB-FUBINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic pathways were alkyl and indazole hydroxylation, terminal amide hydrolysis, subsequent glucuronide conjugations, and dehydrogenation